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Career postings for the Massachusetts Biotechnology Council

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  • 12/04/15--01:07: Sample Management Associate
  • Sample Management Associate will be responsible for the storage, retrieval, replication and distribution of proprietary compound libraries to the screening organization.

     

    For details visit:

    http://www.cwsciences.com/Current-Openings/Sample-Management-Associate-

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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  • 12/04/15--01:09: Process Engineer
  • Process Engineer will be responsible for Design Transfer activities and Validation plans based on process transfer documents with external manufacturing partners.

    For details: http://www.cwsciences.com/Current-Openings/Process-Engineer-GMP

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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    Clinical Sample Coordinator (Part Time) will be responsible for managing and organizing samples.

    For details visit:

    http://www.cwsciences.com/Current-Openings/Clinical-Sample-Coordinator-Part-Time

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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  • 12/04/15--01:13: Trial Coordinator
  • Trial Coordinator will be  responsible for conducting analysis and generating results of completed studies.

    For details visit:  http://www.cwsciences.com/Current-Openings/Trial-Coordinator

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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  • 12/04/15--01:13: QA Specialist I
  • 1) Batch Record Review and Approval
    2) Deviation and Investigations
    3) Metrics reporting

    Must be organized, proactive, possess excellent communication skills and demonstrate desire and ability to quickly learn.


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    Downstream Process Development Associate will support the development of biologics. This includes performing purification using AKTA systems.

    For details visit: http://www.cwsciences.com/Current-Openings/Downstream-Process-Development-Associate

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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    ARIAD is a Cambridge, Massachusetts-based biotechnology company focused on cancer. We are a cohesive team of talented people from diverse backgrounds with a shared vision: We seek to transform the lives of patients with breakthrough cancer medicines. This is our purpose. This is our passion. This is our promise.

    The ARIAD Information Technology organization is undergoing a significant restructuring in order to meet the evolving needs of the company.  This is an exciting time for skilled people leaders with exceptional skills in the IT function to join the senior IT leadership team. The ARIAD Information Technology organization is a dynamic and dedicated team committed to enabling the ARIAD business, and ultimately improving patients’ lives, through solutions, data and information.

     

    The Chief Architect position is a collaborative and effective leader who is a senior member IT organization and is focused on several IT functions and processes. The IT functions supported include (but are not limited to):

     

    • Solution Architecture. Does a solution fit into our platforms and services? Are there other solutions that overlap?
    • Data Architecture. How will information flow, be used and ultimately captured to make better decisions?
    • Security and Compliance.   Do we have the right controls, at the right level? Are we subject to regulatory compliance rules that would need enforcement?
    • Business Continuity. Are we thinking more than just a “back up” for this data, this provider, this process?
    • Technology. Is this the right technology at the right time? What is coming next?

     

    The ideal candidate will demonstrate a high level of initiative, collaboration and influence across IT and various functional communities ensuring exceptional level of delivery of solutions and services. They will be results oriented, an active listener and strong communicator.  They will be a strong cross functional leader who will ensure that the IT strategy will enable the business strategy. They will grow and maintain strong relationships across IT, the functional areas, the greater ARIAD community, and strategic partners engaged for provision of solutions and services.

     

    • Discovery and Research Technologies
    • Chemistry and associated areas
    • Toxicology, Preclinical and associated areas
    • Biomedical Statistics and Data Management
    • Clinical including Clinical Data Management
    • Medical Affairs
    • Pharmacovigilance and Risk Management
    • Clinical Data from First in Human (FIH) through Phase IV
    • Commercial systems including Global Marketing
    • Patient related systems including registries, product websites and other patient facing information
    • Technical Operations including CMOs (Contract Management Organizations)
    • Enterprise Systems including (but not limited to)
      • Finance
      • Human Resources
      • Legal
      • Global Real Estate and Facilities
      • Information Technology

     

    • The Key stakeholders are wide ranging and include the ELT (Executive Leadership Team) and Senior Management team, for example:
      • Chief Medical Officer (CMO)
      • Chief Commercial Officer (CCO)
      • Chief Science Officer (CS)
      • Head of Medical Affairs
      • Head of Marketing
      • Head of Commercial
      • Chief Legal and Administrative Officer
      • Chief Executive Officer (CEO)

     

     

    Job Responsibilities/Ideal attributes:

    • Lead and own the responsibility for exceptionally architected solutions and services in accordance with a strategic IT roadmap.
    • Lead and own the implementation of those solutions in partnership with functional leaders and providers.
    • Critical team member to the technology transformation of ARIAD including the move to a new Headquarters building within Cambridge and the associated technology necessary across global offices (Lausanne, Switzerland, etc.)
    • Active owner of the IT technological roadmap.
    • Stage gate owner of our SLC (System Life Cycle) in determining whether a solution needs validation / qualification in a Regulatory sense.
    • Ability to manage multiple programs of projects, contributes widely, and has intelligent opinions.
    • Strong marketing, influencing and negotiating skills.
    • Proven teamwork, communication and information sharing abilities.
    • Able to work with colleagues, vendors and others with a win-win mindset.
    • Maintains a “focus to finish” demeanor to bring programs to closure and help others attain their goals.
    • An ability to appropriately and effectively partner with senior business leaders and IT leaders
    • An active listener.

    Preferred Qualifications

    • Prior experience in a biotech or mid-sized to large pharmaceutical company.
    • Bachelor’s degree in Business (or Management), Computer Science and/or Engineering.  A Master’s degree or higher is highly desirable. Further degrees would of course be considered.
    • 10-15 years of IT experience in project / program management related to multiple major projects required.
    • 10-15 years using both a strategic mindset and operational demeanor as it applies to technological solutions.
    • Demonstrated ability to appropriately scale information solutions.
    • Knowledgeable expert in some form of related systems / data solutions.

     

    This person is the senior most opinion leader on technology solutions, information and its application throughout ARIAD. Though complex, due to the size of ARIAD, this is a very hands-on role.

     



    Submitting a resume online at a job site could cause valuable screening information to be missed.

    Click here to apply:
    http://ariad-openhire.silkroad.com/epostings/submit.cfm?fuseaction=app.dspjob&jobid=603&company_id=16419&jobboardid=306

    ARIAD is an equal opportunity employer. The Company's policy is to afford equal employment opportunities to qualified individuals without regard to race, color, religion, national origin, ancestry, citizenship, marital status, veteran status, physical or mental disability, sex, sexual orientation or age and to comply with applicable laws and regulations. All employment decisions will be consistent with the principle of equal employment opportunity.


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  • 12/04/15--01:17: Submissions Manager
  • Job Description: The submission manager will be an integral member of Commercial Submission Management (CSM) in Global Oncology and Biologics Operations. On a daily basis, the submission manager will manage activities associated with generating regulatory submissions, including identifying and sourcing submission content, managing and planning submission timelines and projects, overseeing publication activities, and utilizing a wide array of document management, authoring, and publishing tools. The submission manager will also utilize the Common Technical Document (CTD) and the eCTD, and all processes surrounding this capability.

    Duties and Responsibilities:
    • Plan and manage Regulatory submissions, working with GMS (Global Manufacturing and Supply) and GRA (Global Regulatory Affairs) CMC leads to develop and submit filings according to agreed upon processes and timelines.
    • Identify issues that may delay product or project and recommend appropriate action.
    • Manage generation and compilation of Regulatory sections of submissions using electronic document and publishing technology.
    • Apply quality control processes and engage in lifecycle management of submissions to ensure document integrity

    Qualifications:
    Experience: Minimum of 2 years of experience within the pharmaceutical industry and strong project management and/or submission management experience is required. Skill in using desktop applications and proficiency in computer systems and procedures is required.

    Other: Experience in preparing post approval regulatory submissions is highly desired; experience in a Regulatory Submissions organization along with a working knowledge of drug development process is strongly desired.


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  • 12/04/15--01:17: Microbiology Associate
  • Microbiology Associate will be responsible for performing laboratory testing and analysis.   Performs calculations, prepares reports and assesses proper calibration and standardization of equipment and procedures.

    For details visit:

    http://www.cwsciences.com/Current-Openings/Microbiology-Associate

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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    Sr. Research Associate will assist the development of therapeutics in the field of cancer immunology.

    For details visit:

    http://www.cwsciences.com/Current-Openings/Sr-Research-Associate--Cancer-Immunology

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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  • 12/04/15--01:20: QC Research Associate
  • Duties:

    • Perform cell culture, qPCR and ELISA assays.
    • Perform validation activities and interpret analytical data.
    • Assist process development with protocols and reports.

     Background:

    • BS in biology or related area.
    • Must have 1+ years experience with qPCR and cell culture.
    • Must have experience working in a QC environment.

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com


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    Associate Scientist - Cell Based Assays will join a research team and be responsible for the design/execution biology experiments for the identification and validation of drug targets

     

    For details visit:

    http://www.cwsciences.com/Current-Openings/Associate-Scientist--Cell-Based-Assays-

     

    Email resume to: jobs@cwsciences.com

    Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.


    Commonwealth Sciences, Inc.
    http://www.cwsciences.com

     


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  • 12/04/15--01:22: Engineer I
  • Work closely with manufacturing partners to minimize supply chain risks. Work cross-functionally to manage change controls, deviations, investigations. Provide support to regulatory as needed. Manage commercial manufacturing data and data trending. Provide project management support as needed.

    ESSENTIAL FUNCTIONS AND RESPONSIBILITIES: To perform this job successfully, an individual must be able to perform each key function satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the key functions as determined through an interactive discussion with the employee and in consultation with HR and Legal.
    • Provide support to commercial manufacturing associated with biologics drug substance.
    o Support excursions and change management in TrackWise
    o Manage commercial data
    o Project management support
    o Use understanding of project timelines to plan and coordinate with cross functional peers.
    • Proficient in Powerpoint, Excel, Word, JMP, TrackWise
    QUALIFICATIONS: The requirements listed below are representative of the knowledge, skill and/or ability required.
    Minimum Qualifications: Must demonstrate competency in the following areas:
    • Basic project management skills
    • Demonstrate understanding of basic mammalian cell culture and/or purification processes and/or basic scientific background
    Education and/or Experience (including certificates, licenses, registrations):
    • BSc + 0-3 yrs in biopharma or related field
    SKILLS: 
    • Experience managing multiple projects simultaneously
    • Data visualization and presentation
    • Outstanding attention to detail
    • Strong communication skills 
    • Experience with data management systems
    PHYSICAL DEMANDS: (The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions) as determined through an interactive discussion with the employee and in consultation with HR and Legal.
    • Ability to sit and stand for long periods of time.
    • Carrying, handling and reaching for objects.
    • Ability to lift and carry over 15 pounds.
    • Manual dexterity to operate office equipment i.e. computers, phones, etc.


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  • 12/04/15--22:42: Vendor Management Lead
  • Primary Role:
    Vendor Management is an Alliance Management group that sits within GCDO, with the primary responsibility of maximizing the value of the relationships we have with Clinical Vendors supporting Shire's Portfolio (Phase I-IV). The intent is for that value to be translated into improved business terms, increased productivity, reliable quality, strategic innovation and enhanced working relationships. The Director is expected to collaborate with key internal and external stakeholders, at a study, departmental and Alliance Portfolio level to ensure Shire Vendors perform to the highest level. The Director is tasked with the following overarching responsibilities:
    * Build a deep understanding of our Vendors, their organization and capabilities to anticipate opportunities & risks with that Vendor
    * Implement effective governance and build strong relationships to maximize performance and value delivered by that Vendor
    * Create a culture of joint accountability to ensure Vendor performance
    * Facilitate efficient and collaborative resolution of problems and conflicts with vendors and on behalf of vendors within GCDO.

    Responsibilities:
    70%: Management of Assigned Vendors
    10%: Sourcing Strategy/Vendor Selection
    20%: Process Improvement

    Education & Experience Requirements:
    * Bachelors Degree required, preferably in a scientific field; MS, MBA, Ph.D. or other advanced degree preferred
    * 12+ years of experience in project management / relationship management, or leading cross-functional programs, including 5 or more years or more in clinical research, or vendor management in pharmaceutical, biotechnology and/or CRO
    * Education, experience and documented results in providing vendor management support
    * Experience in problem solving, negotiations, presentation and collaborative team-building with non-direct reports required

    Other Job Requirements: Less than 10% domestic and international travel.

    Shire's Brave culture offers employees with diverse backgrounds the opportunity to enable those with life altering conditions to lead better lives. Shire is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by applicable law. US Applicants who require accommodation in the job application process may contact 484-595-8400.

    Application URL:http://www.aplitrak.com/?adid=YXN0YW5pdHMuMzgxNjcuMzE2N0BzaGlyZS5hcGxpdHJhay5jb20


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    Org Marketing Statement
    A career at Pfizer offers opportunity, ownership and impact.

    All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere.Our colleagues have the opportunity to grow and develop a career that offers both individual and company success;be part of an ownership culture that values diversity and where all colleagues are energized and engaged;and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry,is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

    Role Description
    Statistician in a preclinical team focused on all aspects of early preclinical research and development supporting Neuroscience and Pain Research Unit.

    The Research Statistician will be an integral member of a team, which develops and uses computational and statistical approaches to validate and discover disease targets, develop assays around these targets, and derive robust biomarkers. The statistician will play a pivotal role at all stages of experiments from design through signal processing to statistical analysis and interpretation.

    In this position, the Research Statistician will work within the matrix environment collaborating across multiple groups including discovery biology, electrophysiology, imaging, genetics, computational biology, PK/PD modeling, and informatics. She/he will also interface with statisticians and clinicians whose focus is advancing compounds from lead development through Proof of Concept in the clinic.

    Responsibilities
    * Collaborate with scientists across WRD, including Neurodegeneration, Neuroinflammation and Psychiatry teams to design, analyze and present results of the experiments
    * Bring innovative statistical thinking and methods to help drive data-driven drug discovery and development employing modern methods including Bayesian techniques
    * Work with scientists to understand the biology and improve existing or derive new endpoints, utilize prior information, develop 'fit-for-purpose' statistical models
    * Serve as a core member of scientific teams responsible for determining strategy and delivering high quality results in a timely manner
    * Use statistical expertise to prepare both internal and external reports, presentations, manuscripts

    Qualifications
    PhD in Statistics, Biostatistics or in quantitative discipline such as Physics, Applied Mathematics, Bioengineering, Electrical Engineering coupled with high level of statistical expertise. Research experience with mathematical/statistical modeling using complex data and five or more years of postdoctoral or industrial experience are preferred.

    * Strong background in experimental design and statistical analysis including good understanding of inference and probability, competence in contemporary linear and predictive modeling including (longitudinal) mixed models, nonlinear regression, and predictive modeling
    * Expert level knowledge of machine learning algorithms with robust feature selection and optimization
    * Experience with development and validation in biomarker studies, including analysis of imaging and/or electrophysiological data
    * Comprehensive knowledge of methods of signal processing including image segmentation and/or electrophysiological data analysis
    * Genuine interest in biology, preferably Neuroscience.
    * The attitude of self-directed scientist; demonstrated ability to multitask
    * Outstanding communication skills; ability to explain modeling concepts to non-experts
    * Demonstrated ability to work effectively as a part of a team
    * Demonstrated ability to effectively deal with ambiguity and change

    Technical Skill Requirements:
    * Expert level knowledge of statistical programming environments such as R and/or SAS
    * Expert level knowledge of scientific programming in MATLAB and/or Python, along with low level languages C/C++/Fortran
    * Hands-on experience with high-performance computing, Unix environment, scripting, are preferred

    EEO & Employment Eligibility
    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

    Application URL:http://www.aplitrak.com/?adid=SmFtZXMuQ3JvbmluLjk1OTM3LjMxNjdAcGZpemVyLmFwbGl0cmFrLmNvbQ


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    Org Marketing Statement

    A career at Pfizer offers opportunity, ownership and impact.

    All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere.Our colleagues have the opportunity to grow and develop a career that offers both individual and company success;be part of an ownership culture that values diversity and where all colleagues are energized and engaged;and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry,is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

    Role Description
    This research position is located at the department of Global Biotherapeutics Technologies in Pfizer Worldwide Biotherapeutics Research campus of Cambridge, MA. This individual will work in the area of therapeutic protein production and engineering in mammalian cells. The individual will perform molecule biology, mammalian cell culture, large-scale bioreactor mammalian cell expression, and protein production analysis for supporting protein therapeutics discovery efforts. The individual will perform this function with supervision, toward considerable independence, and will display initiative in learning new techniques.

    Responsibilities
    - Carry out molecular biology, mammalian cell culture, transient/stable transfection, expression analysis with ProA capturing, analytical SEC, immunoblotting, and scale-up in bioreactors.
    - Maintain and operate 10L bioreactors for cell culture scale-up, perform downstream medium harvesting and concentrating.
    - Perform calculations and draws conclusions regarding progress and results of work.
    - Assist with the organization and maintenance of cell line stocks and plasmid DNA stocks
    - Quickly learns and accurately performs new procedures involving a range of technologies.
    - Demonstrate oral and written presentation skills.
    - Prepare and present project summaries at team meetings, GBT meetings, and through monthly summary reports.
    - Contribute to the preparation of papers for peer review journals.

    Qualifications
    - A Bachelor Degree is required, preferably with a Life Science major.
    - A Bachelor Degree and a minimum of 6+ years of relevant laboratory experience, or a Master Degree and a minimum of 5+ year of relevant laboratory experience.
    - Mammalian protein expression experience, large-scale CHO/HEK293 stable/transient expression experience is preferred.
    - Training in molecular biology and/or mammalian cell biology and experimental experience using cell culture techniques.
    - Understanding of the principles involved in molecular and cellular biology and/or cell culture techniques.
    - Demonstrated capability to conduct complex experiments in parallel.

    PHYSICAL/MENTAL REQUIREMENTS:
    Lifting, bending, and ability to perform mathematical calculations and ability to perform complex data analysis

    NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT

    REQUIREMENTS:
    Weekend cell culturing or cell feedings are required from time to time.

    EEO & Employment Eligibility
    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

    Application URL:http://www.aplitrak.com/?adid=QWxpc29uLlR1dGx5cy45MjQ1NS4zMTY3QHBmaXplci5hcGxpdHJhay5jb20


    0 0

    Org Marketing Statement

    A career at Pfizer offers opportunity, ownership and impact.

    All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere.Our colleagues have the opportunity to grow and develop a career that offers both individual and company success;be part of an ownership culture that values diversity and where all colleagues are energized and engaged;and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry,is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

    Role Description
    Senior Scientist in the Eating Disorders Group in the Department of Cardiovascular, Metabolic and Endocrine Diseases (CVMET), reporting to the Molecular and Cellular Receptor Pharmacology lab head.
    -The individual will work closely with in vivo biologists and apply strong background in GPCR pharmacology to drug discovery and the development of innovative therapeutic approaches for metabolic and eating disorders including obesity.
    -The candidate will have extensive in vitro experience in the characterization of GPCRs, in particular the quantification of orthosteric and allosteric modulator actions at GPCRs expressed in recombinant as well as human isolated native cellular systems.

    Responsibilities
    -Elucidate the molecular mechanisms and functional impact of signal transduction mediated by GPCRs in recombinant and primary cell systems relevant to metabolic diseases and eating disorders (e.g. neuronal cells) using a combination of optical, biochemical, pharmacological and molecular biological approaches.
    -Develop innovative research plans and assays that can drive project progression by enabling a deeper understanding of the molecular pharmacological properties leading to optimal therapeutic efficacy and safety of GPCR modulators (e.g. affinity, potency, binding kinetics, signaling efficacy on multiple functional endpoints, impact on receptor trafficking kinetics, bias signaling, allosterism, etc.)
    -Evaluate and incorporate whenever possible cutting-edge technologies, new receptor theories and models to drive creative molecular research on GPCRs.
    -Ensure productive interactions with scientist from cross-disciplinary teams partnering with CVMET, including the primary pharmacology, Structural Biology, and Medicinal Chemistry groups.
    - Prepare reports, present scientific data and advise project teams on the most suitable cellular system and in vitro experimental endpoints to characterize the effect and mode of action of receptor modulators.

    Qualifications
    * MSc with 5+ years or PhD in biochemistry or pharmacology preferably with industrial experience. The ideal candidate will have a strong history of rigorous technical accomplishments.
    -A proven record of the development, execution and interpretation of classical receptor ligand binding and functional experiments to characterize the actions of agonists or antagonists at GPCRs.
    * Hands-on experience with non-traditional methods and concepts related to GPCR biology is a plus (e.g. Bio-luminescence/ Forster energy transfer (BRET/ FRET), TIRF microscopy (TIRF), high content screening, label-free platforms, biased signaling, etc).
    * Strong organization skills coupled with an ability to plan and execute work unsupervised and to mentor junior colleagues both technically and scientifically.
    * Excellent communication and interpersonal skills, strong self-motivation, and ability to work both independently and as part of a team. Creative individual with desire to acquire and apply knowledge to test new scientific hypotheses.

    PHYSICAL/MENTAL REQUIREMENTS
    -Mainly work at the lab bench, sitting, standing or walking.
    -Work at a desk sitting

    EEO & Employment Eligibility
    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

    Application URL:http://www.aplitrak.com/?adid=TWVnYW4uSGFycmlnYW4uMzU3NjUuMzE2N0BwZml6ZXIuYXBsaXRyYWsuY29t


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  • 12/05/15--00:30: Postdoc, Immunology
  • Our team, led by Dr. Ramnik Xavier, aim to understand the determinants of mucosal tolerance and immunity. To this end, our lab is using a combination of physiologically relevant cell-based assays, genome editing, novel mouse models, and computational analyses.We are looking for postdoctoral associates to identify the components of the innate and adaptive immune systems that interact dynamically in human health and disease.

    Recent studies in our group have uncovered a novel role for CLEC12A as an early adaptor molecule in antibacterial autophagy (PMID: 26095365); used a CARD9 rare variant, that confers protection against inflammation, to uncover a TRIM62-mediated mechanism for regulation of CARD9 activation (PMID: 26488816); and identified DYRK1A as a physiologically relevant regulator of regulatory T cell differentiation (PMID: 25998054). Current projects include

    (1) generate novel mouse models using cutting edge technologies, such as CRISPR, to uncover mechanisms of pathogenesis by inducing inflammation using infectious, non-infectious, and immune cell transfer models;
    (2) perform functional genomic screens to place disease-associated genetic variants in pathways;
    (3) examine the interactions between host genetics and the microbiome during inflammation; and
    (4) determine the role of novel autophagy genes in antibacterial defenses in vivo, as well as characterizing cell-specific functions of those genes.

    Requirements
    - Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology
    - Maximum 0-2 years of related postdoc experience preferred
    - Well versed in the application of mouse models
    - Strong publication record in high-impact journals
    - Excellent communication skills and the ability to work as a team member are essentialEOE/Minorities/Females/Protected Veterans/Disabilities#LI-POST

    To apply for this position, please CLICK HERE


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  • 12/05/15--00:34: Postdoc, Autophagy
  • The autophagic delivery of intracellular pathogens to the lysosome is emerging as a central mechanism of innate and adaptive immunity. The broad objectives of the Xavier lab are to identify new candidate host genes and pathways that contribute to the induction of autophagy (perform genome-wide CRISPR screens, biochemical analysis, and analysis of mutant animals to define target mechanisms), and to develop successful strategies to increase autophagy in cells, thereby leading to new strategies to treat infectious diseases and disorders of mucosal immunity.Postdoc positions in our group are available to

    (1) study molecular mechanisms of selective autophagy;
    (2) determine the role of novel autophagy genes in antibacterial defenses in vivo and identify cell-specific functions of those genes; and
    (3) identify small molecules that target selective autophagy.

    • Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology
    • Maximum 0-2 years of related postdoc experience preferred
    • Well versed in the application of mouse models
    • Strong publication record in high-impact journalsEOE/Minorities/Females/Protected Veterans/Disabilities

    To apply for this position, please CLICK HERE


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    OVERALL RESPONSIBILITY
    The Xavier group uses a combination of cell-based assays, novel mouse models, patient samples, and computational analyses to understand the pathogenesis of inflammatory diseases and accelerate their treatment. We are seeking a highly motivated postdoctoral researcher to join an exciting initiative aimed at identifying small molecules that target the regulatory networks governing gut mucosal immune responses.

    As a member of our team, the postdoctoral researcher will establish and perform assays aimed at developing and optimizing small molecule probe compounds with the desired characteristics. These probes will then be used

    (1) to better understand the mechanisms that modulate gut innate immune responses in health and disease, and
    (2) as leads for therapeutics. The role entails working with assay development and high throughput screening scientists, and closely collaborating with a team that includes immunologists, clinicians, computational biologists, and chemists to enable iterative rounds of compound testing and optimization.

    CHARACTERISTIC DUTIES
    - Responsible for the specification, implementation and validation of assays for high-throughput screening.
    - Performs detailed characterization of hits and chemically optimized compounds.
    - Determines the feasibility and makes recommendations regarding the acquisition and/or implementation of new technologies, reagents and assay procedures.
    - Uses demonstrated scientific creativity, collaboration with others and independent thought to expand technical capabilities and identify new research opportunities. - Ph.D. in immunology, cell biology or biochemistry. Background in autophagy strongly preferred.
    - Solid experience in the development of biochemical and/or cell-based assays.
    - Experience working with primary cells and mouse disease models a plus.
    - Strong publication record and excellent communication skills.
    - Excellent organization and time management skills required.
    - Must be able to handle a variety of tasks and to adapt to a highly dynamic environment.

    EOE/Minorities/Females/Protected Veterans/Disabilities#LI-POST

    To apply for this position, please CLICK HERE


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