Position Summary
We seek a highly skilled and motivated senior scientist who is an expert in modern proteomics. The candidate will expand the capabilities of our existing LC/MS laboratory and establish new state of the art tools with the goal of characterizing therapeutic and endogenous proteins, as well as protein-mRNA interactions. The Proteomics Sr. Scientist will work with other Moderna scientists and external groups to expand the fundamental understanding of the impact of exogenous mRNA-directed therapeutic protein generation on disease biology.
Responsibilities
* Expand state of the art proteomics laboratory
* Establish peptidomics- and proteomics-based strategies for characterization of exogenously delivered mRNA-cellular protein interactions
* Apply new methodologies for characterization of mRNA-encoded proteins
* Hire and supervise proteomics scientific staff members
Minimum Qualifications
* Ph.D. in chemistry, biochemistry, cell biology or a related discipline
* Extensive experience with mass spectrometry with 5 years of postdoctoral/industrial experience
* Ability to manage, maintain, and employ Orbitrap-based mass spectrometry platforms, as well as experience in HPLC/Auto-sampler utilization
* Experience with computational tools for protein identification, statistical analysis and visualization/interpretation of mass spectrometric data
* Proven experience with LC/MS analysis of biological samples derived from in vitro and in vivo sources
* Knowledge of affinity purification techniques for isolation of biomolecules; experience in handling mammalian cells
* Willingness to engage and ability to coordinate multiple collaborative projects in a cross-functional team environment
* Experience in quantitative approaches including MRM, PRM and reference peptide analysis
Preferred Qualifications
* Ph.D. with at least 8 years of industry experience in protein sciences
* Relevant publications in peer-reviewed journals expected in support of candidacy
* Familiarity with mRNA biology
* Ability to multi-task to meet technology development and research goals
Competencies
* Effective Communication
* Independence/Teamwork
* Applied Learning
* Customer Focus
* Ability to inspire and supervise staff members
* Technical/Professional Knowledge
Why Join Moderna
Moderna is pioneering messenger RNA Therapeutics™, an entirely new in vivo drug modality that produces human proteins or antibodies inside patient cells, which are in turn secreted or active intracellularly. This breakthrough platform addresses currently undruggable targets and offers a superior alternative to existing drug modalities for a wide range of disease conditions. Moderna has developed a broad intellectual property estate, including more than 250 patent applications covering novel nucleotide chemistries and drug compositions. The company plans to develop and commercialize its innovative mRNA drugs through a combination of strategic relationships as well as newly formed ventures.
Founded in late 2010 by Flagship VentureLabs, Cambridge-based Moderna is privately held and currently has strategic agreements with AstraZeneca and Alexion Pharmaceuticals.
Moderna recently signed a collaboration agreement with Astra Zeneca that provided a $240MM upfront payment (plus milestone payments).
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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