Codiak Biosciences is leveraging recent advances in the biology of extracellular vesicles and their role in intercellular communication. Codiak aims to become the world’s leading company in developing exosomes as a new therapeutic and diagnostic modality for the treatment of a wide array of diseases, including cancer. Recent discoveries have demonstrated that exosomes derived from normal cells can act as a potent and safe delivery system for multiple therapeutic payloads. These small vesicles, which leave cells and travel throughout the body, can mediate dramatic effects in animal models of disease. The group has also shown that exosomes derived from cancer cells contain specific proteins on their surface that can be used to quickly detect and characterize cancer from a sample of patient’s blood. They can also be used to monitor the response to cancer treatment, and to detect relapses.
Codiak Biosciences is seeking a creative and accomplished exosome/extracellular vesicle biologist with a demonstrated record of exosome production, isolation, and characterization. The position is for a bench scientist who can design and execute studies that address fundamental questions of exosome biology while helping to scale early exosome production for pre-clinical and early clinical studies.
Success in this role will rely heavily on flow cytometry, ELISA, and protein engineering, but an ability to pick up diverse characterization tools and methods will be necessary as research progresses. Cell culture experience is a plus.
This is a unique opportunity for a strong scientist to contribute experimentally, as well as intellectually, to both a drug discovery and a diagnostic development research program. As part of a start-up the candidate will be uniquely exposed to the full range of company activities within and outside the lab. The candidate will also play a critical role in helping shape Codiak’s scientific and business direction.
Qualifications
- PhD in biology, biochemistry, drug discovery, or a related subset thereof. Post-doc experience is appreciated, but not necessary.
- Should be a motivated biologist with a background in oncology, immunology or cell biology.
- Development experience with cell and biochemical assays.
- The ability to work well independently, and as part of the growing Codiak team, and be able to quickly design and execute thoughtful experiments.
- An aptitude for efficient and dynamic experimental design is critical in early development and the need to prioritize, and then re-prioritize, diverse studies is invaluable.
Additional qualifications include, but are not limited to;
- Exosome isolation and characterization
- Primary cell and ex-vivo analysis of cells and tissues
- Flow cytometry and ELISA assays
- Vector construction and transduction
- Experience with design and execution of mouse trials
- Experienced in protein, DNA and RNA methods including western blot analysis, recombinant DNA technology, and RT-PCR
- Diagnostic development and validation experience is a plus
Those interested in contributing to Codiak Biosciences’ development of the nascent and exciting field of exosome biology may email their CV and any relevant credentials to Careers@codiakbio.com.