Org Marketing Statement
A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere.Our colleagues have the opportunity to grow and develop a career that offers both individual and company success;be part of an ownership culture that values diversity and where all colleagues are energized and engaged;and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry,is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Role Description
Apply and develop chemical biology techniques to advance drug discovery projects in the CardioVascular and METabolic (CVMET) disease area, through a number of methods including: design, synthesis, purification and characterization of modified proteins and/or nucleotides or complexes thereof (ribonucleoproteins); the design and application of chemical probes to biological systems; the use of chemical biology expertise to influence medicinal chemistry design strategies for drug discovery projects.
Accountabilities of the role include producing knowledge that delivers significant impact upon CVMET projects by driving effective design and synthesis interactions to advance projects from exploratory stages to delivery of clinical candidates. Accountabilities of the role also include survival of candidates to positive clinical proof of concept (POC).
*The role is based in Cambridge Massachusetts but will initially be located at the University of California at Berkeley as part of a research collaboration for at least 6 months.
Responsibilities
* Design, synthesis, purification and characterization of modified proteins and/or nucleotides or complexes thereof (ribonucleoproteins)
* Design of single guide RNAs (sgRNA)
* Design and apply functional chemical probes that address a specific need of the project teams in CVMET using effective partnerships with synthetic/medicinal chemistry and biophysics groups.
* Use of proteomics for pathway interrogation and to identify opportunities for therapeutic intervention in disease where the biologic target and/or mechanism of action for active molecules is not known.
* Use affinity/activity-based proteomics, photoaffinity probes and cellular imaging agents to assess binding sites, off-target effects, post-translational protein modifications and biological mechanisms.
* Identify and examine modulators of enzymes, receptors, transporters, ion channels or other biological targets with unique mechanisms of action using chemical biology techniques.
* Exploit scientific expertise of analytical chemistry, structural biology, data analytics within the Pfizer WWMC community as appropriate to ensure that appropriate technologies are applied to solving design problems.
* Work in conjunction with computational, design and synthetic chemists, biologists, pharmacologists, structural biologists, ADME and safety scientists to advance projects within the Research Unit.
* May be responsible for leading projects at a strategic chemistry design level.
Qualifications
Doctoral level degree or equivalent
Postdoctoral experience is preferred
Essential Training and Experience:
* Strong track record of delivering biological insights through chemical biology experimentation.
* Experience working on biological systems including cloning, expression and purification of proteins; quantitative gene expression and proteomic techniques; mammalian and bacterial tissue culture.
* Experience working with Clustered Regularly Interspaced Short Palandromic Repeats (CRISPR) and CRISPR associated (Cas) protein systems type I and II.
* Structure biology experience with Cas proteins
Additional Training and Experience
* Experience with peptides, proteins, cells, cell lysates, ex vivo tissues, etc.
* Design of sgRNA
* Comfortable applying analytical and purification techniques used in chemical biology, i.e. gel electrophoresis, Western blots, LCMS, ELISA and molecular probe design.
* Experience in target identification and mechanism of action elucidation
* Experience working in a majority of the following areas would be desirable:
medicinal/organic chemistry, click chemistry, site-selective protein modification, photoaffinity
cross-linking, genetic encoding of unnatural amino acids, affinity enrichment, cellular imaging, and/or proteomics.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
* The role will require periodic visits to the Groton Connecticut site for face-to-face meetings and training.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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