Senior/Staff Scientist: Molecular and Cell Biology/Antibody
About Acceleron:
Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel therapeutic candidates that regulate cellular growth and repair. The company is a leader in understanding the biology of the Transforming Growth Factor-Beta (TGF-β) protein superfamily, a large and diverse group of molecules that are key regulators in the growth and repair of tissues throughout the human body, and in targeting these pathways to develop important new medicines. Acceleron has built a highly productive R&D platform that has generated innovative clinical and preclinical protein therapeutic candidates with novel mechanisms of action. These protein therapeutic candidates have the potential to significantly improve clinical outcomes for patients with cancer and rare diseases.
Position overview:
We are seeking an experienced and highly motivated Scientist with expertise in molecular and cellular biology with focus on biologics discovery and development to join our R&D team. This hire will play a key role in the development of unique new products and will be required to interact across teams internally as well as with external parties. This person will be responsible for management of antibody projects, including vector construction, antibody production in mammalian cells and antibody characterization. In addition the candidate will be involved in the construction and in vitro evaluation of various discovery molecules using different cellular assay formats such as reporter gene assays, flow cytometry, ELISA, etc. We are looking for a candidate who has demonstrated a natural flair for innovation, outstanding analytical skills, and the ability to manage complex projects from conception to completion. Experience in supervising the work of others and managing key collaborator relationships would be a great advantage. You will have a self-starting attitude, willing to go to lab to get the project started, leadership qualities, excellent interpersonal and organizational skills, and the ability to work under tight deadlines. The title will be determined based on the experience.
Basic Qualifications:
- PhD in molecular biology, cell biology, biochemistry or related field
- 5-10 years of recent hands-on experience in development of protein therapeutics
- Ability to manage all aspects of the design, engineering, and generation of protein therapeutics (especially monoclonal antibodies)
- Technical expertise in molecular and cellular biology, cloning, vector construction, mammalian cell culture and cell line development is essential.
- Detailed understanding of biologics production and process optimization including antibodies is required
- Previous experience working with bispecific antibodies is a plus.
- Hands-on experience in design, implementation and troubleshooting of cell based assays including reporter gene assay development, FACS, MSD, ELISA, etc along with data interpretation is required
- Ability to distill complex issues and clearly articulate innovative solutions
- Ability to communicate effectively by oral presentation, written technical reports, and scientific publications
- Ability to lead, influence and motivate others
- Highly analytical mind, attention to details, and organizational skills are critical
- Highly self-motivated with a strong sense of responsibility and a collaborative spirit.
- Strong communication, interpersonal and teamwork skills are essential
*Recruiters - please do not send unsolicited resumes to this posting.
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