Ginkgo is building an industrialized foundry for organism engineering. Our first foundry, Bioworks1, launched in Spring 2015. We designed Bioworks1 to be a single foundry capable of delivering many organisms to customers in many markets. Already, we're using Bioworks1 to concurrently develop 10+ organisms across multiple species and products.

At the heart of Bioworks1 is high throughput genetic engineering across multiple species. Our approaches are designed to scale 100-1000X via software and automation. We are seeking genetic engineers to improve and scale our existing technologies in Biowork1 and define and develop the next set of genetic technologies that will lie at the center of Bioworks2.

The ideal candidate has led the development of a high-throughput biological process from development, validaton through to successful operation at scale, most likely for DNA synthesis or sequencing. A demonstrated ability to evolve a process in response to changing technology and demands is essential. Experience in a mixed team of software developers, process engineers, and biologists is important.

RESPONSIBILITIES

• Operate and improve processes for strain modification in Bioworks1
• Apply DOE approaches to refine and improve genetic methods
• Translate genetic methods and tools to be performed by software + automation
• Work hand in hand with software and automation engineers to scale up genetic methods and tools 100-1000X
• Develop processes for verification and quality control of constructed genetic parts and strains

REQUIREMENTS

• BS or MS in biology, microbiology, genetics or equivalent
• Experience with molecular biology and/or genetic engineering of microbes
• Familiarity with software or laboratory automation a plus

To learn more about Ginkgo, check us out on Medium and BuzzFeed

https://medium.com/the-os-fund/a-new-era-of-industrial-engineering-using-biology-dd4571aa6d27

http://www.buzzfeed.com/stephaniemlee/this-startup-is-designing-yeast-to-make-brand-new-scents-fla#.ph2jnprJK

We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack - we can’t afford to leave any talent untapped. It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

www.ginkgobioworks.com

Join bluebird bio’s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. Be a critical part of a team tasked with helping to shape the market access landscape for gene therapy.  Conceive of and execute innovative Pricing Market Access and Health Economics initiatives to support bluebird bio’s gene therapy and evolving oncology portfolio. Contribute to the creation of market access strategies worthy of bluebird bio’s innovative therapies and the patients they are meant to serve.

About the role:

• Lead bluebird’s in-market preparation for successful price and access negotiations
• Identify and engage stakeholders to understand the requirements for gene therapy reimbursement submissions in select European markets at the national, regional, and local levels
• Partner with stakeholders to establish appropriate assessment processes where none currently exist
• Thoroughly explore existing local reimbursement and funding mechanisms and communicate clear insights to leadership
• Assist in the assessment of payment model options
• Partner with Medical and Patient Affairs to identify local physician and patient groups
• Identify local data sources to augment/fill gaps in economic models
• Act as a core member of a working team tasked with the evaluation commercial models for Europe

About you:

• Advanced degree with 8+ years of experience in biotech/pharma with a demonstrated ability to work cross functionally
• Experience as in-country market access lead preferably for the UK, Germany, Italy, and/or France
• Prior experience leading a reimbursement submission as well as pricing, reimbursement, and access negotiations
• Robust network including access decision makers in key countries
• Strong analytical, communication and project management skills to effectively translate ideas and insights into actionable plan
• Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities
• Excellent communication skills and ability to influence across multiple functions.
• Be ready to embrace the principles of the bluebird bio culture:  b colorful, b cooperative, and b yourself

Ginkgo is building an industrialized foundry for organism engineering. Our first foundry, Bioworks1, launched in Spring 2015. We designed Bioworks1 to be capable of delivering many organisms to customers in many markets. Already, we're using Bioworks1 to concurrently develop 10+ organisms across multiple species and products.

At the heart of Bioworks1 is high throughput genetic engineering across multiple species. Our approaches are designed to scale 100-1000X via software and automation. We are seeking genetic engineers to both scale our existing technologies in Biowork1 and define the next set of genetic technologies that will lie at the center of Bioworks2.

The ideal candidate has led the development of a high-throughput biological process from scale-up through to successful operation, most likely for DNA synthesis or sequencing. A demonstrated ability to evolve a process in response to changing technology and demands is essential. Experience in a mixed team of software developers, process engineers, and biologists is important.

RESPONSIBILITIES

• On-board new species into the foundry
• Develop new genetic methods and tools that are multi-species
• Translate genetic methods and tools to be performed by software + automation
• Work hand in hand with software and automation engineers to scale up genetic methods and tools 100-1000X
• Develop processes for verification and quality control of constructed genetic parts and strains

REQUIREMENTS

• PhD or equivalent plus 5+ years of industrial experience
• Prior experience in one or more of the following: high throughput pipelines, laboratory automation, software engineering, NGS, DNA synthesis and assembly, genome engineering

To learn more about Ginkgo, check us out on Medium and BuzzFeed

https://medium.com/the-os-fund/a-new-era-of-industrial-engineering-using-biology-dd4571aa6d27

http://www.buzzfeed.com/stephaniemlee/this-startup-is-designing-yeast-to-make-brand-new-scents-fla#.ph2jnprJK

We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack - we can’t afford to leave any talent untapped.

www.ginkgobioworks.com  

We are passionate about engineering organisms at Ginkgo Bioworks. We're guessing you are too.

We believe that engineering organisms requires an integrated, industrialized technology pipeline. Over the past few years that's what we've been building at Ginkgo. Our first foundry Bioworks1 includes robotic automation, novel DNA assembly biochemistry, custom CAD/CAM software, high resolution LC-MS, and much more. We built it for people like you.

You have experience in rational design of genetic systems, but also understand the benefits of mutation and evolution in building better strains. You're excited to work with both software developers and organism engineers to develop real design principles for biology. You have insight into leveraging high-throughput DNA synthesis to design effective screens and selections.

Take a look at the following statements -

* You are a student of other engineering fields and look for lessons for engineering biology

* You think that computers are a bad metaphor for a cell

* You recognize that biology is a unique engineering substrate that comes pre-loaded with startlingly brilliant code we didn't write

* You think most people engineering organisms are undisciplined in their approach

* You recognize that we are at the beginning of engineering organisms and that there will never be another chance like this to define the field.

If these statements describe you well and you feel up to the challenging position described above, perhaps you should apply to Ginkgo Bioworks.

REQUIREMENTS

• Ph.D. or equivalent
• Previous success engineering at least one organism - plants, fish, microbes, worms, fungi ... it doesn't matter, as long as it worked.
• Few years post-graduate experience with a second organism a plus.

To learn more about Ginkgo, check us out on Medium and BuzzFeed

https://medium.com/the-os-fund/a-new-era-of-industrial-engineering-using-biology-dd4571aa6d27

http://www.buzzfeed.com/stephaniemlee/this-startup-is-designing-yeast-to-make-brand-new-scents-fla#.ph2jnprJK

We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack - we can’t afford to leave any talent untapped.

www.ginkgobioworks.com 

Job ID: 26500
Date Posted: 10/08/2015
Date Closed: 05/11/2015
Location: 450 Brookline Ave
Job Family: Technician/Technologist
Full/Part Time: Full-Time
Regular/Temporary: Regular
About Dana-Farber

Located in Boston, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Overview

The mission of Dana-Farber Cancer Institute is to provide expert, compassionate care to children and adults with cancer while advancing the understanding, diagnosis, treatment, cure, and prevention of cancer and related diseases.

Our Core Values are:

Impact - Above all else, we make a difference by relieving the burden of disease now and for the future through our research, clinical care, education, outreach and advocacy.

Excellence - We pursue excellence relentlessly and with integrity in all that we do, adhering always to the highest standards of conduct.

Compassion and respect - For those in our care and for one another.

Discovery - We foster the spirit of inquiry, promoting collaboration and innovation across traditional boundaries while celebrating individual creativity.

The Bing Center for Waldenstrom’s macroglobulinemia (WM) is a Center within the Institute that is dedicated to the genomic discovery and clinical treatment of the lymphoplasmacytic lymphoma called Waldenstrom’s macroglobulinemia.

A full-time position is available for a highly motivated research technician who performs basic technical procedures as directed and to examine translational aspects of this disease. The laboratory uses a variety of biochemical, cell biology, and translational approaches to identify new therapeutic targets and develop preclinical models. The position offers the opportunity to eventually lead research efforts along with responsibility for high-throughput screening and routine laboratory tasks. This highly integrated goal-oriented Center provides an unprecedented opportunity to change the way anti-cancer therapeutics are discovered and developed. For more information please visit our website at www.bingcenterforwm.org

The ideal candidate will be motivated, goal-oriented, and possess excellent organizational, communication, and analytical skills. BS/MS in biological sciences with a minimum of 2 years research experience in academic and/or pharmaceutical/biotech environment. Training experience working in a medical or scientific research setting or comparable technology-oriented business environment is preferred.

Baseline procedures include but are not limited to: (1) pipetting; cell and tissue culture, etc., (2) has understanding of molarity, (3) prepares basic solutions, (4) conducts analysis of results, and may begin interpretation of results, (5) sets up and prepares experiments as directed and may perform multiple techniques independently. Previous experience in mammalian cell culture, Western blotting, immuno-precipitation, and immuno-fluorescence staining and DNA sequence and gene expression data analysis a plus.

The position will be supervised by a senior lab technician, post-doctoral staff or principal investigator. This position will not have direct supervisory responsibilities. A Lab book recording and monthly review is mandatory.

Schedule

Schedule

M- F Initial hours 9:00 – 5:00+; hours will be more flexible once trained and mediated by assigned projects.

How to Apply

Please apply directly online at http://www.dana-farber.org/Careers/Careers-at-Dana-Farber.aspx. Click Search Job Openings and use the Job ID number to quickly locate the appropriate job listing. Once you have located the desired job, click on the checkbox in the 'Select' column, and then click the 'Apply Now' button, located at the bottom of the screen.

DFCI Employees please apply directly through PeopleSoft Self Service. Sign on to PeopleSoft and navigate to Main Menu > DFCI Careers.

Equal Employment Opportunity

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Apply Here

PI92289577

RaNA Therapeutics is looking for an AP and Payroll Administrator to join our growing team! The ideal candidate for this role is a detail-oriented team player who learns quickly, communicates effectively, and feels motivated by a fast-paced environment. This position reports to the Manager of Accounting and External Reporting, and will be responsible for the full cycle of accounts payable and the accurate administration of the payroll process.

Responsibilities:

• Responsible for timely and accurate posting of invoices into Great Plains
• Verify the accuracy of invoices and purchase orders for payment
• Ensure taxes are properly captured on invoices
• Match invoices to purchase orders and/or receiving documentation
• Ensure proper approvals and coding for invoices
• Process weekly checks and wire transfers for payment
• Track all cash transactions, prepare journal entries and perform the bank reconciliation on a monthly basis.
• Manage vendor records and reconcile vendor statements as needed 
• 1099 Preparation
• File paid invoices weekly
• Ensure all payroll is process on a timely basis
• Process withholdings, garnishments, as well as fringe benefits such as 401K deductions
• Use ADP to maintain up to date employment records
• Respond to frequent requests for information, reports and audit requests
• Assist with the monthly close process where necessary to maintain high productivity and efficiency in the department
• Participate in annual audit
• Assist in building a strong internal control structure at RaNA

Experience:

• Required experience in Accounts Payable and Payroll Administration, preferably in the biotech/pharma industry; 3-5 years
• Experience with Great Plains and ADP is helpful but not required
• Bachelor’s Degree with emphasis in accounting is preferred
• Excellent communication and organizational skills
• Strong attention to detail
• Team player that can handle multiple tasks simultaneously in a fast growing company, work independently with little supervision provided, good time management skills, and a willingness to exert extra effort as required
• Comprehensive knowledge of Microsoft Word and Excel

RaNA Therapeutics, located in Cambridge, Massachusetts, is pioneering the discovery and development of a new class of RNA-based therapeutics that selectively increase protein production. We focus on developing treatments for diseases with a significant unmet need that are difficult or impossible to address with existing technologies. Our lead programs include the upregulation of SMN2 for the treatment of Spinal Muscular Atrophy and the upregulation of frataxin for the treatment of Friedreich’s Ataxia. Along with these lead programs, we are exploring the therapeutic benefit of targeting other rare genetic diseases, musculoskeletal diseases and inflammatory diseases. We are dedicated to translating cutting-edge science in the areas of gene regulation, lncRNA and epigenetics into drugs that will have a significant impact in the treatment of life-threatening diseases.

RaNA Therapeutics is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.

RaNA Therapeutics, located in Cambridge, Massachusetts, is pioneering the discovery and development of a new class of RNA-based therapeutics that selectively increase protein production. We focus on developing treatments for diseases with a significant unmet need that are difficult or impossible to address with existing technologies. Our lead programs include the upregulation of SMN2 for the treatment of Spinal Muscular Atrophy and the upregulation of frataxin for the treatment of Friedreich’s Ataxia. Along with these lead programs, we are exploring the therapeutic benefit of targeting other rare genetic diseases, musculoskeletal diseases and inflammatory diseases. We are dedicated to translating cutting-edge science in the areas of gene regulation, lncRNA and epigenetics into drugs that will have a significant impact in the treatment of life-threatening diseases.

Part-time Assistant Animal Care Technician

RaNA is looking for a part-time Assistant Animal Care Technician to join our team, working weekends and holidays. This person will be working in RaNA Therapeutics Animal Care Facility.

Responsibilities and Requirements:

• Carry out basic animal husbandry which will include: Animal health observation, animal receiving, receiving animal feed, recording environmental control parameters (temperature and humidity), cage changing, cleaning and mopping animal holding rooms and procedure rooms, stocking PPE, disinfecting and sanitizing animal facility.
• A commitment to the care and welfare of animals
• Close attention to detail
• Ability to keep accurate record of ACF
• Ability to work as part of a team
• Strictly follow Guides, SOPs and policies of the ACF
• Available to work weekdays, weekends, holidays.
• Previous experience of working with mice and rats
• ALAT and LAT certifications preferred, but not required

To apply, please send your resume and work availability to careers@ranarx.com

RaNA Therapeutics is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.

Scientist, Bioanalytical Development

About Acceleron:

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel therapeutic candidates that regulate cellular growth and repair.  The company is a leader in understanding the biology of the Transforming Growth Factor-Beta (TGF-β) protein superfamily, a large and diverse group of molecules that are key regulators in the growth and repair of tissues throughout the human body, and in targeting these pathways to develop important new medicines. Acceleron has built a highly productive R&D platform that has generated innovative clinical and preclinical protein therapeutic candidates with novel mechanisms of action.  These protein therapeutic candidates have the potential to significantly improve clinical outcomes for patients with cancer and rare diseases. 

Position Overview:

We are searching for an enthusiastic individual to establish an LC-MS/MS platform for detection of large molecule therapeutics in a range of matrices.  The successful candidate will work alongside of our ligand-binding group to design quantitative assays for our clinical and preclinical platforms, with assays supporting pharmacokinetic/toxicokinetic determination and biomarker evaluation, using chromatography and mass spectrometry.  This individual will be responsible for assay development, optimization and transfer to external contract organizations as well as periodic preclinical sample analysis.  The candidate must design, interpret and execute experiments independently, and demonstrate experience with multi-dimensional extraction techniques such as HPLC separations and affinity enrichment of proteins, including immunoaffinity approaches.  The candidate should also be able to independently design and execute targeted peptide quantitative methods using a triple-quadrupole mass spectrometer. He/she will be required to write and review protocols and reports and to assimilate and evaluate data.  Knowledge of pharmacokinetics and Phoenix/WinNonlin software is a plus.  Some travel is required for scientific oversight of outsourced contract laboratories.

Basic Qualifications:

• The successful candidate should have a Ph.D. in Biochemistry, Analytical Chemistry, or related discipline with 3+ years of relevant industry experience in mass spectrometry based proteomics
• In-depth knowledge of and hands-on experience with LC-MS/MS based quantification of proteins
• Direct experience with the operation, maintenance, and trouble-shooting of triple quadrupole mass spectrometers
• Experience in proteomic sample preparation from biological matrices including primary blood
• Experience with assay development/validation for large biomolecules and a working understanding of immunoassay technologies
• Strong problem solving skills
• Ability to communicate effectively with management as well as laboratory personnel

*Recruiters - please do not send unsolicited resumes to this posting.

FOR IMMEDIATE CONSIDERATION PLEASE VISIT OUR WEBSITE AT:

www.acceleronpharma.com

• Seek opportunities to collaborate with academic and industry partners and organizations as appropriate in order to develop novel formulation strategies for complex drug products under development.
• Collaborate with Drug Delivery and Device partners and other Lilly teams, as appropriate, on identification and strategic planning of new formulation research  development opportunities.
• Collaborate with Discovery organizations in Indianapolis and San Diego to identify partnership opportunities and build expertise on  developing innovative formulation solutions for new assets in the portfolio
• Identify and spearhead research efforts in challenging formulation fields such as (i) high conc/ high vol biologics; (ii) Sub-cutaneous delivery mechanisms; (iii) co-formulation strategies for macromolecules; (iv) preservative compatibility with bioproducts
• Identify and spearhead research efforts on understanding new drug delivery technologies in the areas of targeted drug delivery and other novel drug delivery fields, and establish proof of concept for technologies for appropriate assets under development
• Establish and leverage strategic relationships with academia and start-ups to accelerate and access emerging innovation.
• Lead the establishment of new platforms that may emerge from the innovative drug product formulation and delivery projects by effectively collaborating with other CMC functions and manufacturing organizations.
• Ability to wear multiple functional hats so that input into various complementary parts of the project can be managed in a rapid and localized manner
• Innovate or Assess cutting edge formulation methodologies for complex or unstable bioproducts (peptides, proteins, fusion proteins and drug conjugates)
• Ability to lead others in the design, execution and interpretation of experiments to drive the definition and optimization of formulations
• Coaching, training and administration of performance management to personnel (primarily, but not limited to, direct reports)

Basic Qualifications

• PhD in Pharmaceutics or Pharmaceutical Sciences or Biochemistry or Chemical Engineering or related field
• 7 to 10 years of experience in the pharmaceutical or biotech industry in developing novel formulation technologies or drug delivery technologies, including material science and characterization

Additional Skills/Preferences

• Comprehensive  knowledge and understanding of (1)  proteins, degradation pathways, and general approaches for stabilization, (2) parenteral manufacturing and aseptic technologies, and drug product process development
• Experience with supervision of scientists and engineers
• Breadth of knowledge of the pharmaceutical drug development process
• Significant experience and technical leadership in developing high concentration formulations of Monoclonal Antibodies
• Significant experience and technical leadership in developing Insulin formulations and other peptide formulations
• Significant experience and technical leadership in developing novel drug product delivery projects, liposomes and nanoparticles
• Proven track record in drug product process development, and integration of container-closure and device delivery systems including prefilled syringes and autoinjectors
• Experience in leading groups of individuals in formulation development, and significant supervision experience; Must be able to work productively in an interdisciplinary team environment
• Demonstrated problem solving and decision-making skills; as well as influencing and negotiation skills

Research Scientist/ Sr. Research Scientist- Formulations Development
The Research Scientist is responsible for conducting and/or leading scientists involved in assessing new formulation and drug delivery technologies, conducting preformulation and formulation of parenteral and novel delivery systems, and  performing device and drug delivery feasibility studies on biomolecule projects including peptides, proteins and monoclonal antibodies.  The scientist is also responsible for leading / supporting organization initiatives, bringing new capabilities / technologies and providing internal / external influence. KEY OBJECTIVES/DELIVERABLES:
The responsibilities for this role will include:

• Innovate or Assess cutting edge formulation methodologies for complex or unstable bioproducts (peptides, proteins, fusion proteins and drug conjugates)
• Partner effectively with Device and Packaging in innovating and evaluating new drug delivery and device technologies
• Work in teams focusing on research on understanding subcutaneous drug delivery, formulation impact on immunogenicity and pharmacokinetics, high concentration/ high volume formulations, preservative compatibility with bioproducts etc.
• Interface with academia and external partners to identify novel formulation and drug  delivery  technologies as related to device  that can be assessed further for adoption by Lilly
• Solve formulation or process development challenges through fundamental understanding of molecular attributes
• Design of parenteral formulations using preformulation principles to support development of clinical formulations (lyophilized and solution) and commercial drug product.  Provide support for successful manufacture of clinical supplies.
• Keep abreast of relevant new technologies / capabilities and regulatory initiatives / requirements.
• Participate/Lead in efforts to influence the scientific community within and outside of Lilly to help advance Lilly’s scientific presence.
• Authoring of technical reports , research grants and journal publications and regulatory documents
• Ability to lead others in the design, execution and interpretation of experiments to drive the definition and optimization of formulations
• Coaching, training and administration of performance management to personnel (primarily, but not limited to, direct reports)

Basic Qualifications

• PhD in Pharmaceutics or Pharmaceutical Sciences or Biomedical Engineering or Biochemistry or Chemical Engineering or related field
• Experience/ knowledge of drug delivery and device technologies

Additional Skills/Preferences

• Basic understanding of proteins, degradation pathways, and general approaches for stabilization
• Able to independently contribute from the bench (design and execute studies to develop a formulation)
• Post-doctoral or additional relevant industry experience; 2 to 4 years experience in pharma or biotech company is highly desirable
• Experience/ knowledge of parenteral formulations development for clinical and commercial use (including lyophilized and solutions formulations).
• In depth understanding of protein chemistry, structure and conformation, as relates to chemical and physical stability of small and large molecules.
• Demonstrated technical / scientific leadership skills; applied to problem-solving
• Good oral and written communication skills,Must be able to work productively in an interdisciplinary team environment

Do you believe yourself to be an excellent Clinical Project Manager?  Are you able to oversee and manage early and late stage clinical studies? Are you willing to work with a small team? Than this job is for you! My biopharma client is looking for someone with the experience you possess.  
Responsibilities:
• Management of CROs, study timelines, study drug packing and distribution activities
• Prepare budgets for clinical studies and be able to handle variances in the budget, as well as project study enrollment and drug supply
• Ensure compliance with company’s quality measures
Requirements:
• BA/BS in a related field, with 5-7 years of clinical project experience
• Over 3 years of clinical trial management
• Experience with clinical development, especially Oncology, Imaging, and ex-US experience preferred
• Ability to perform CRO selection, negotiate proposals and determine if needs of clinical trial is met

About StratAcuity

Whether you are seeking a career change or simply interested to become part of our network, you will appreciate the ethics guiding each StratAcuity team member. We build lasting relationships with exceptional scientists and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a StratAcuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

CHEMISTRY IS EVERYTHING™

Job ID: 27333
Date Posted: 11/09/2015
Location: 44 Binney St, Boston
Job Family: Clinic Admin Sup Specialist
Full/Part Time: Full-Time
Regular/Temporary: Regular
About Dana-Farber

Located in Boston, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Overview

The mission of Dana-Farber Cancer Institute is to provide expert, compassionate care to children and adults with cancer while advancing the understanding, diagnosis, treatment, cure, and prevention of cancer and related diseases.

Our Core Values are:

Impact - Above all else, we make a difference by relieving the burden of disease now and for the future through our research, clinical care, education, outreach and advocacy.

Excellence - We pursue excellence relentlessly and with integrity in all that we do, adhering always to the highest standards of conduct.

Compassion and respect - For those in our care and for one another.

Discovery - We foster the spirit of inquiry, promoting collaboration and innovation across traditional boundaries while celebrating individual creativity.

The David B. Perini, Jr. Quality of Life Clinic is a multidisciplinary consult service in Pediatric Oncology that sees childhood cancer survivors of all ages. The Clinic is part of the Perini Family Survivors’ Center.

The Clinical Administrative Support Specialist (CASS) greets patients, schedules and confirms appointments, and complete clerical work. The CASS serves as a vital communication link between patients, families, visitors and staff and is the main contact to the Clinic for all patients. He/she assists with the coordination of support activities that contribute to the smooth operation of the clinical area. The CASS actively contributes to the Quality Assessment and Improvement program. The position requires demonstrated organizational skills with attention to detail, thoroughness, practical decision-making, excellent communication skills and a commitment to team work. Indirect patient care activities support efficient clinic operations and may include ordering and stocking of patient education materials. The Mission, Vision and Core Values of the Dana-Farber Cancer Institute are incorporated into all areas of practice.

Essential Functions:

• Works directly with physicians and nurse practitioners to facilitate continuity of care among providers on the Perini Team and to facilitate referral to specialists when appropriate
• Schedules appointments following guidelines that support safe clinical practice, patient comfort, continuity of care for complex visits, and a high standard of timely communication and rescheduling as necessary
• Responsible for appropriately tapping resources to support the highest standard of patient care

Principal Duties and Responsibilities:

1. Serves as one of the initial contacts for patients, families, visitors and staff.
2. Triages telephone calls, as appropriate, for both new and established patients and processes detailed clinical information provided by patients, inside and outside providers, and others, such as staff from ancillary services. Either manages problems directly or ensures appropriate management of call by others
3. Must recognize emergencies and appropriately respond using standard operating procedures and critical thinking skills
4. Provides general disease or program-specific information to callers and refer calls as necessary
5. Provides systems, process, and customer service training to co-workers and other staff members as needed
6. Assists patients with the process of obtaining medical records and lab results

.

B. Establishes rapport with patients and families from a variety of cultural, ethnic and religious

backgrounds.

1. Communicates difficulties and concerns that patients and families are experiencing to appropriate staff.
2. Responds to needs of patients and families, including need for wheelchair or interpreter.
3. Maintains patient and family privacy and confidentiality.
4. Considers age-specific needs when interacting with patients.

New patient-specific functions

• Provides information regarding available services to prospective new patients and referring physicians
• Obtains baseline clinical information for new patients and determines appropriate patient/physician assignments
• Collects basic demographic information and enters in to Perini database
• Receives and processes medical record information from outside institutions
• Schedules patient visits, ranging in complexity from one physician appointment to multiple care provider appointments
• Assists patients in gathering relevant clinical materials for initial visit: records, films, pathology, and labs
• Provides information to the patient regarding the need for insurance referral(s), and refers calls as appropriate
• Ensures a smooth transition from referral call to registration to billing/financial counseling
• Coordinate specialty services referrals when appropriate
• May establish clinical trials appointments and assemble necessary paper work for a visit

Established Patients

• Serves as a clinical liaison for patients
• Schedules patient visits, ranging in complexity from one physician appointment to multiple care provider appointments
• Schedules ancillary appointments including labs, radiology, cardiology and pulmonary function testing appointments
• Provides information to the patient regarding the need for insurance referral(s), and refers calls as appropriate
• Prepares and word processes brief letters regarding patient care i.e.: for travel or return to work.
• Assists in processing paperwork associated with clinical care including: insurance claims, disability forms and medical equipment forms
• Supports ongoing clinical trials visits and manages schedules based on investigator’s availability to see the patient

Schedule

Monday - Friday, 8:30 - 5pm

How to Apply

Please apply directly online at http://www.dana-farber.org/Careers/Careers-at-Dana-Farber.aspx. Click Search Job Openings and use the Job ID number to quickly locate the appropriate job listing. Once you have located the desired job, click on the checkbox in the 'Select' column, and then click the 'Apply Now' button, located at the bottom of the screen.

DFCI Employees please apply directly through PeopleSoft Self Service. Sign on to PeopleSoft and navigate to Main Menu > DFCI Careers.

Equal Employment Opportunity

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Apply Here

PI92289236

GENERAL SUMMARY OF POSITION:

The Process Engineer II is responsible for employing good engineering practices (GEP) to apply principles, theories, concepts, industry practices/ standards, and to provide engineering support of biological manufacturing and/or process development operations and capital projects. Additionally, the Process Engineer II applies quality by design (QbD) concepts to evaluate, specify, recommend and order equipment that is both technically feasible and cost effective; in particular, cGMP/sterility driven equipment designs and processes. Assists in the development of engineering test studies to acquire data on a variety of process equipment, utilities, components, products, and systems to optimize process performance and/or reliability. Assists with technology transfer and process scale-up engineering. Builds productive internal/external working relationships.

MAJOR RESPONSIBILITIES:

• Assist senior level engineers (PE III/PE IV) to provide support in equipment design, selection, installation, and commissioning.
• Collaborates with vendors or subject matter experts in the development of User Requirements Specifications (URS) and equipment functional specifications (FS) in support of equipment selection and qualifications.
• Generates draft revisions of controlled documentation in support of equipment installation, process changes, product changeover, etc. (SOPs, change controls, P&IDs, deviations, work orders, specifications, amendments, etc.) throughout the scope of a project.
• Assists Facilities by providing engineering support in the maintenance and repair of equipment and systems.
• Supports Validation in the execution of installation and operation verification (IOV), as well as performance qualification (PQ).
• Assists with investigations with potential engineering impact.
• Assists manufacturing with troubleshooting, root cause analysis, and identifying corrective actions to restore the qualified state of a system, equipment, or process. Ensure that process equipment is maintained in a validated state.
• Works effectively with the Automation group to clearly define the scope of the process, alarms, set-points, etc. to optimize the process control strategy. Collaborate with automation to define new equipment, system, or processes for specifications and design basis of new control systems.
• Identifies and implements cGMP/sterility, operability, safety and maintenance driven equipment designs and processes; participate in risk based analysis to assure quality, reliability and cost effectiveness of product.
• Works on problems of moderate scope where analysis of situations or data requires review of a variety of factors. Exercises judgment within defined procedures and practices to determine appropriate action.
• Performs other additional job related duties as required.

MINIMUM QUALIFICATIONS:

• Requires a Bachelor’s degree in engineering with a minimum of 2 years relevant experience
• Requires at least 1 year prior pharmaceutical/biotech manufacturing or process development experience; experience in clean room (e.g. cell culture, purification or fill/finish) preferred
• Executes routine assignments with minimal supervision/direction. Demonstrated excellent time management and organizing skills
• Maintains effective communication with customers and collaborates with departments to ensure engineering activities are executed efficiently and effectively
• Ability to consistently meet deadlines
• This position may require working off hours depending on the needs of the manufacturing and/or process development

Must be able to carry out the essential functions of this position, with reasonable accommodation if disabled

Apply Here

PI92290875

Department: Research Administration - Clinical Trials Business Office

At Boston Children’s Hospital, success is measured in patients treated, parents comforted and teams taught. It’s in discoveries made, processes perfected, and technology advanced. In major medical breakthroughs and small acts of kindness. And in colleagues who have your back and patients who have your heart. As a teaching hospital of Harvard Medical School, our reach is global and our impact is profound. Join our acclaimed Clinical Trials Business Office, and discover how your talents can change lives. Yours included.

Responsibilities:

• Conducting prospective reimbursement analysis such as Medicare coverage analysis, for clinical trials
• Drafting and negotiating clinical trial budgets with study sponsors.
• Additionally, sharing with other CTBO staff the management of the segregation and routing of charges related to the treatment of patients enrolled in clinical trials.
• Other functions which may include invoicing sponsors based on study milestones and pre-negotiated payment terms, tracking payments, and assisting in study account close-out procedures.
• Communicating with Investigators and study teams to ensure proper financial oversight of their clinical trials on continuous basis 

Qualifications:

• Knowledge of theories, principles, and concepts typically acquired through completion of a Bachelor's degree in Science, Public Health, or other discipline, and 3 years of experience coordinating or managing clinical trials.
• Familiarity with protocols, study coordination, and clinical trials financial management is preferred.
• Experience with preparing and negotiating budgets for corporate-sponsored clinical trials is highly desirable, as well as having experience conducting prospective reimbursement analysis (i.e., Medicare coverage analysis).
• Demonstrated experience reviewing, comprehending and interpreting complex clinical trial protocols, informed consent forms, clinical practice guidelines, and clinical trial agreements is preferred.
• Experience working directly with investigators and sponsors is preferred.
• Medical coding experience is highly desirable.
• A strong interest in continual learning and improvement.

Benefits:

Boston Children’s Hospital offers competitive compensation and unmatched benefits, including affordable health, vision and dental insurance, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition Reimbursement, cell phone plan discounts and discounted rates on T-passes (50% off). Discover your best.

Equal Opportunity:

Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.

Status:Full Time

Shift:Day

Schedule: Mon. - Fri.

Standard Hours per Week:40

AutoReqId:37773BR

Apply Now: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?jobId=2180977&partnerid=368&siteid=5205&Codes=IIND 

GENERAL SUMMARY OF POSITION:

The Process Engineer I is responsible for employing good engineering practices (GEP) to apply principles, theories, concepts, industry practices/ standards, and to provide engineering support of biological manufacturing and/or process development operations and capital projects. Additionally, the Process Engineer I applies quality by design (QbD) concepts to evaluate, select, and order equipment that is both technically feasible and cost effective; in particular, cGMP/sterility driven equipment designs and processes. Assists in the development of engineering test studies to acquire data on a variety of process equipment, utilities, components, products, and systems to optimize process performance and/or reliability. Assists with technology transfer and process scale-up engineering. Builds stable working relationships internally.

MAJOR RESPONSIBILITIES:

• Provides support with specifications, equipment selection, installation, and commissioning of process equipment for manufacturing, utilities, or process development.
• Generates draft revisions of controlled documentation in support of equipment installation, process changes, product changeover, etc. (SOPs, change controls, P&IDs, deviations, work orders, specifications, amendments, etc.) throughout the scope of a project.
• Assists Facilities by providing engineering support in the maintenance and repair of equipment and systems.
• Supports Validation in the execution of installation and operation verification (IOV), as well as performance qualification (PQ).
• Assists manufacturing with troubleshooting, root cause analysis, and identifying corrective actions to restore the qualified state of a system, equipment, or process.
• Works on problems of limited scope. Follows standard practices and procedures in analyzing situations or data from which answers can be readily obtained.
• Performs other additional job related duties as required.

MINIMUM QUALIFICATIONS:

• Requires a Bachelor’s degree in engineering with a minimum of 0 -2 years relevant experience
• This position may require working off hours depending on the needs of the manufacturing and/or process development groups
• Prior pharmaceutical manufacturing or process development in a cGMP environment preferred
• Excellent written and verbal communication skills
• Ability to consistently meet deadlines
• Ability to perform routine tasks independently utilizing time management and organizational skills

Must be able to carry out the essential functions of this position, with reasonable accommodation if disabled

Apply Here

PI92290869

www.genocea.com

Genocea Biosciences is a small fast-growing vaccine discovery and development company based in Cambridge, Massachusetts. Genocea is harnessing the power of T cell immunity to develop the next generation of vaccines and immunotherapies. 

Senior Research Associate

Position Summary

We are seeking an Associate to join our Research Department in Cambridge, MA.  The ideal candidate is a motivated, energetic, detail-oriented person who will design and carry out experiments with limited supervision.  Position involves making contributions to experimental design and data analysis.  Must have the capacity to adapt, and demonstrate a strong desire to learn new concepts and techniques.  Expected to work well within a dynamic and team-oriented small company environment.

Primary Responsibilities

• Immunological-based techniques including ELISA-based assays, and functional T cell assays (e.g., antigen presentation, ELISPOT, Luminex, multicolor flow-cytometry).
• Animal modeling of infection and vaccination.
• Cell culture and molecular biology techniques (qPCR, western blots, etc).
• Independently design experiments, analyze data and prepare reports.
• Maintain basic knowledge of principals in field(s) at hand.
• Prepare slide decks independently and present them for internal company meetings.
• Maintain literature files and accurate laboratory records and notebooks.
• Troubleshoot experimental process under minimal supervision.

Required Skills

• A solid theoretical understanding of and experience with cellular and molecular immunology techniques. Assay development experience is a plus.
• Proficiency with in vivo mouse models of infection or disease.
• Ability to analyze data, draw conclusions, communicate results and compile technical reports.
• Excellent record keeping abilities to adequately record and document analytical data.
• Solid technical knowledge and hands-on experience.
• Ability to work effectively in a cross-functional setting.
• Capacity to adapt, with a strong desire to learn new concepts and techniques.
• Excellent communication, problem solving and analytical skills. Strong organization and ability to multi-task.

Education & Experience

Master’s degree with a minimum of 3 years or Bachelor’s degree with a minimum of 5 years of experience in biopharmaceutical industry

To apply for this position, please CLICK HERE

www.genocea.com

Genocea Biosciences is a small fast-growing vaccine discovery and development company based in Cambridge, Massachusetts. Genocea is harnessing the power of T cell immunity to develop the next generation of vaccines and immunotherapies. 

Bioassay Scientist

Position Summary

Seeking a top notch contributor to join our dynamic and dedicated team. The Bioassay Scientist will be expected to plan and execute experiments as well as analyze data generated by other internal and external contributors. The candidate will have demonstrated hands-on experience with in vivo and cell-based potency assays, technology transfer, data analysis and troubleshooting. The successful candidate will supervise a small team that supports the evaluation of immunogenicity and efficacy of candidate vaccine formulations both in mouse models and in vitro. He/she will work closely with our Biopharmaceutical Development and Production group to support our vaccine development programs with reliability, integrity, and commitment while working in a cross-functional setting.

Competencies and Responsibilities

•  Provide technical resource for bioassay method development, optimization, implementation and validation.
• Assist with feasibility studies and method transfers within and outside of Genocea.
• Routine review of method performance, design and execution of remediation experiments should discrepancies be identified, and development and implementation of improvements to existing assay methods.
• Assist in maintaining critical reagent supply and instrumentation for assigned methods.
• Write animal use protocols, SOPs, validation protocols, and study reports.
• Work collaboratively across organization and sites for method readiness, transfer, performance and troubleshooting.
• Work closely with Biopharmaceutical Development and Production, Vaccine Development, and Translational Medicine team members to understand their deliverables to achieve organization goals.
• Ability to work independently and as a part of a cross-functional team with a positive attitude.
• Performance of in vivo and in vitro bioassays for vaccine development, comparability, potency, and lot release studies.
• Demonstrated experience with bioassay method development, qualification and validation is necessary.
• Experience with vaccine potency assays is a plus.

Education and Experience Requirements

•  PhD with a minimum of 4 years of relevant experience with bioassays and immunoassays in biologics process development.
• Relevant experience in industry is a must.

To apply for this position, please CLICK HERE

www.genocea.com

Genocea Biosciences is a small fast-growing vaccine discovery and development company based in Cambridge, Massachusetts. Genocea is harnessing the power of T cell immunity to develop the next generation of vaccines and immunotherapies. 

Anti-Microbial Vaccines Sr. Scientist / Group Leader

Position Summary

We are seeking a top notch contributor to join our dynamic and dedicated team. Reporting directly to the Director of Vaccines in the Vaccine Development group, the Sr. Scientist/Group Leader will be expected to apply an understanding of microbial host-pathogen interactions towards the development of new vaccines candidates against Chlamydia trachomatisand Streptococcus pneumoniae among others. The candidate will contribute with both technical and intellectual expertise to many levels of the program, including development of the overall strategy, antigen screening and prioritization, adjuvant testing, immunization approaches, animal modeling, and external collaborations. The successful candidate will supervise a team that supports the evaluation of immunogenicity and efficacy of candidate vaccine formulations in animal models and clinical trials. He/she will develop collaborations to advance Genocea’s vaccine strategy through strong alliance management, driving publications, and representing the company at key scientific meetings.

Competencies

•  Excellent communication, problem solving and analytical skills
• Deep knowledge of microbial pathogenesis, host-pathogen interactions, and animal models of human disease
• Understanding of microbial immunity
• Solid technical knowledge and hands-on experience with immunological and microbiological techniques
• Experience in vaccine development

Primary Responsibilities

• Work collaboratively with other departments to characterize and identify the specificity of T cell responses toChlamydia trachomatis and Streptococcus pneumoniae, and design and evaluate novel vaccines or immunotherapies
• Plan, implement and directly supervise complex projects; assume lead role in providing solutions to difficult problems associated with specific projects
• Perform experiments at the bench to test hypotheses
• Support R&D collaborations as a technical expert and scientific liaison
• Draft manuscripts for publication in peer-reviewed journals
• Budget development
• Ensure technical quality and compliance
• Presentation of technical data both internally and at scientific conferences

 Required Skills

•  Critical interpretation of data, including ability to formulate suggestions for alternate approaches for data generation and evaluation
• Familiarity with current scientific literature and ability to select methods and techniques for obtaining solutions within accepted practices and procedures
• Experience mentoring and managing multiple direct and indirect reports
• Demonstrated leadership skills, with evidence of successful development and management of timelines
• Broad knowledge of state-of-the-art principles and theory
• Exceptional degree of sustained ingenuity, creativity and resourcefulness
• Ability to apply and/or develop highly advanced technologies, scientific principles, theories and concepts that may be new to the industry
• Experience working with both Gram negative (i.e. Chlamydia) and Gram positive (i.e. Pneumococcus) organisms
• High-level creative problem solving and analytical skills, using technical discretion in the design, execution and interpretation of experiments that contribute to project goals

Education Requirements

MD or PhD with 7-10 years of relevant experience in infectious diseases, immunology, microbiology or related field. Relevant experience in industry is a plus.

To apply for this position, please CLICK HERE

Who We Are

ImmunoGen is a clinical-stage biotechnology company that develops targeted anticancer therapeutics with its proprietary antibody-drug conjugate (ADC) technology. The Company's lead product candidate, mirvetuximab soravtansine, is a potential treatment for folate receptor α-positive ovarian cancers and other solid tumors. Leading healthcare companies have licensed rights to use ImmunoGen's technology to develop novel anticancer therapies, and Roche's marketed product, Kadcyla, utilizes ImmunoGen's ADC technology. More information about the Company can be found at www.immunogen.com.

The Director will report to the VP of Manufacturing Operations and have a dotted reporting line to the  EVP Technical Operations.  He/she will lead a team of EH&S professionals and will be required to support and influence leadership across a broad range of technical and scientific disciplines.   Strong alignment and coordination with other Technical Operations, Research and Development groups will be critical. The Director will be responsible for building and implementing the corporate EH&S strategies and plans and ensuring they remain in alignment with business priorities and goals

Primary Responsibilities to include:

• Provide strategic leadership of ImmunoGen’s various Environmental Health and Safety initiatives  and programs such that ImmunoGen continues to improve performance and strengthen its safety culture.
• Interpret, implement and ensure ImmunoGen remains compliant with all applicable EH&S regulations and directives.
• Chair various internal organizational teams/committees that help develop ImmunoGen’s Environmental & Safety mission, policies, and respective goals/objectives
• Serve as an agent of the company and representative/liaison to a variety of external entities including federal, state, and local agencies, suppliers, manufacturing partners, industry related groups and community entities.

Essential Functions:

• Establish, oversee implementation and maintenance of all environmental, health, safety and industrial/occupational hygiene policies, programs and systems, promoting state of the art safe and healthful work practices for the protection of personnel, physical assets and operations.
• More specifically, partner with key stakeholders to build and implement an EH&S management system in accordance with a recognized international or national standard such as OHSAS 18001 or a comparable framework. The new EH&S management system is to be integrated and compatible with other ImmunoGen systems in order to have EHS standards apply throughout all operations and continues to strengthen the companys safety culture.
• Ensure maintenance of appropriate site licenses, chemical inventory systems, hazardous waste documentation, isotope use and disposal documentation…
• Establish functional priorities and goals and identify performance improvement targets and metrics ensuring talent and capabilities in place to effectively deliver on all commitments and performance targets.
• Optimize company’s technical resources by deploying and modelling robust talent development, performance management, and succession planning and rewards/recognition practices.
• Ensure that the EH&S team is staffed appropriately. Build and nurture employee engagement by creating environment within which staff can grow and excel. Serve as coach/mentor.
• Prepares annual and multi-year financial budgets and forecasts. Manage headcount and expenses to meet approved spending plans while delivering on commitments.
• Stay current with current industry standards, new trends, technologies and technical developments and all applicable regulations.

Who You Are

• Bachelors or advanced degree in chemistry, biochemistry or related discipline with strong Occupational Health & Safety training/experience and at least 12-15 years of industrial EH&S experience.
• Deep experience in pharmaceutical / biopharmaceutical industry EH&S.
• Demonstrated leadership is a must, ideally 10+ years leading teams/departments responsible for EH&S.
• Experience in leading chemical hygiene and biosafety programs required.  High potency compound containment experience strongly preferred.  Radiation safety experience a plus.
• Must have strong knowledge of local, state and federal EH&S regulations and guidance. Knowledge of global EH&S regulations and requirements preferred.
• Demonstrated ability to manage technically and operationally complex programs and to balance the strategic needs of the program with tactical day-to-day activities.

ImmunoGen, Inc. is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status.

ImmunoGen, Inc. does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on ImmunoGen, Inc.’s approved agency list. Unsolicited resumes or candidate information submitted to ImmunoGen, Inc. by search/recruiting agencies not already on ImmunoGen, Inc. approved agency list shall become the property of ImmunoGen, Inc. and if the candidate is subsequently hired by ImmunoGen, Inc., ImmunoGen, Inc. shall not owe any fee to the submitting agency.

Momenta Pharmaceuticals is currently looking for an experienced Business Systems Analyst who will support Oracle E-Business Suite, Workday and other potential enterprise resource planning (ERP) applications as well as maintain the production state of business process configurations and customizations. The Business Analyst will actively engage the business teams to assess needs, evaluate functionality and support Oracle E-Business Suite Modules including General Ledger, Payables and Receivables, Purchasing, iProcurement, Fixed Assets, and Cash Management, as well as participate in Workday HCM activities including vendor management, managing system integrations and future module evaluations.  The Business Analyst will commit to ongoing business process improvements and maximizing operational efficiencies.  This individual will be gathering requirements, writing functional design documents, communicating requirements to technical team members, testing, implementing, and training.

Key Responsibilities:

• Support and enhance Oracle Applications interfaces integrated with non-Oracle systems
• Provide production support on day-to-day issues
• Serve as a liaison between business users and internal, external technical team members
• Compose, maintain and review system documentation such as requirement specifications, design specifications and test scripts
• Facilitate the prioritization of projects, requirements and support issues among competing business interests
• Support Noetix reporting platform and provide reports to various stakeholders
• Identify process improvements and work with business partners effectively to implement change
• Evaluate new technologies and identify how they meet our business needs